429 Elevated Phosphate Levels Induce Lung Inflammation and Exacerbate Pulmonary Fibrosis
OBJECTIVES/GOALS: Using a cell culture model, we will determine the effects of phosphate on primary lung cell cultures and use our results to delineate a pathway through which these changes are carried out.Using animal models, we will determine the effects of phosphate on inflammatory and fibrotic lung injury, both in the presence and absence of CK